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Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); rpn1-evi1

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An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) resulting in the reposition of a distal gata2 enhancer to activate mecom expression. It may present de novo or follow a myelodysplastic syndrome. The clinical course is aggressive.

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