Acute-phase protein
Acute-phase protein
The acute-phase proteins (pronunciation: /əˈkjuːt ˈfeɪz ˈprəʊtiːn/) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. This response is called the acute-phase reaction (also known as acute-phase response).
Etymology
The term "acute phase protein" is derived from the observation that these proteins' levels increase or decrease dramatically in response to inflammation, which is often a sign of an acute phase of illness.
Function
Acute-phase proteins help the body to restore homeostasis after tissue injury. They are mainly produced in the liver and are released into the circulation in response to pro-inflammatory cytokines.
Types of Acute-phase proteins
There are two types of acute-phase proteins: positive and negative. Positive acute-phase proteins include C-reactive protein, serum amyloid A, fibrinogen, and procalcitonin. Negative acute-phase proteins include albumin and transthyretin.
Related Terms
- C-reactive protein
- Serum amyloid A
- Fibrinogen
- Procalcitonin
- Albumin
- Transthyretin
- Inflammation
- Cytokines
- Liver
- Proteins
External links
- Medical encyclopedia article on Acute-phase protein
- Wikipedia's article - Acute-phase protein
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