Ad sig hmuc 1/ecdcd40l adenoviral vector vaccine
Ad sig hmuc 1/ecdcd40l adenoviral vector vaccine - a cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor associated antigen (taa) human muc 1 (hmuc 1) linked to the extracellular domain (ecd) of the co stimulatory molecule cd40 ligand (cd40l) and an adenovirus signal sequence that encodes a secretory signal peptide (ad sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by ad sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hmuc 1 and the cd40l ecd. The cd40l moiety part of the fusion protein binds to cd40 receptors on dendritic cells (dcs). Subsequently, dcs may be activated and migrate, t cells may expand, and a cytotoxic t lymphocyte (ctl) response against tumor cells that overexpress hmuc 1 may follow. Muc 1 is a hypoglycosylated taa overexpressed by epithelial cancer cells.
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