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Adecatumumab

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adecatumumab

A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM) with potential antitumor activity. Adecatumumab binds to EpCAM, which may result in antibody-dependent cellular cytotoxicity (ADCC) directed against EpCAM-expressing tumor cells. EpCAM (CD326), a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells; for some cancers, overexpression has been correlated with decreased survival.


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Monoclonal antibodies for tumors

Human ("-tumu-") * Adecatumumab§
Mouse ("-tumo-")

ltumomab pentetate

 

altumomab_pentetate

Chimeric ("-tuxi-") * Amatuximab§
Humanized ("-tuzu-") * Abituzumab§
Rat/mouse hybrid

("-tumaxo-")

* Catumaxomab
Chimeric + humanized

("-tuxizu-")

* Depatuxizumab mafodotin
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials: 
    • †Phase III
    • §Never to phase III
 

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