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Adeno-associated virus (AAV)

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A virus used to construct vectors that introduce genes into cultured cells. Recently, researchers started to use AAV as a convenient vector for expression ofshort hairpin RNA (shRNA)inRNAistudies.

AAV integrates into the host cell genome very inefficiently and appears not to generate immune response, but as a vector it cannot carry large genes. It is potentially useful for "hit and run" gene therapy, where a single burst of therapeutic gene expression is desired.

More about adeno-associated viruses and RNAi inPubMed.

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