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Adenosine, 8-chloro-

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Adenosine, 8-chloro- - an antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-atp), which functions as a ribonucleoside analogue and competes with atp during transcription. Therefore, this agent causes rna synthesis inhibition, inhibits cellular proliferation, and induces apoptosis. Also see 8-chloroadenosine

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Adenosine, 8-chloro- for any updates.


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