Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,682 pages, 4,140,315 edits & 38,438,347 views.

Free unbiased diet, health and wellness info!

Adenosine A2A receptor antagonist PBF-509

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Adenosine A2A receptor antagonist PBF-509 is a stub. If you are familiar with the topic Adenosine A2A receptor antagonist PBF-509, you can help us. Paid editors welcome!


 

Adenosine A2A receptor antagonist PBF-509 is part of WikiMD's free ^articles!

^Adenosine A2A receptor antagonist PBF-509 (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available