Information about Sulfadiazine
Sulfadiazine is a sulfonamide antibacterial agent used in the therapy of mild-to-moderate infections due to sensitive organisms.
Liver safety of Sulfadiazine
Sulfadiazine, like other sulfonamides, is a well known cause of clinically apparent, idiosyncratic liver injury.
Mechanism of action of Sulfadiazine
Sulfadiazine (sul" fa dye' a zeen) is an orally administered sulfonamide antibiotic that acts by inhibition of folic acid synthesis, which is required for bacterial replication and growth.
FDA approval information for Sulfadiazine
Different forms of sulfonamides have been used in clinical medicine since the 1930s. Sulfadiazine was approved for use in the United States in 1973. Current indications are many and include urinary tract infections and otitis media due to sensitive organisms.
Clinical use of Sulfadiazine
Sulfadiazine is also used as prophylaxis against rheumatic fever and meningococcal meningitis. It is used in combination with pyrimethamine for prevention and treatment of toxoplasmosis and is also effective in nocardiasis, chancroid, and trachoma. It is used as adjunctive therapy for chloroquine-resistant malaria and several forms of bacterial meningitis.
Dosage and administration for Sulfadiazine
Sulfadiazine is available in multiple generic forms in tablets of 500 mg. For urinary tract infections, the usual dose is 2 to 4 grams daily in 3 to 6 divided doses. Common side effects are diarrhea, nausea, gastrointestinal upset, rash and fever.
The following are sulfonamide drugs
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Learn more about Sulfadiazine
- Dailymed label info
- Scientific articles
- Drug portal Sulfadiazine
- toxicity info on Sulfadiazine
- FDA Sulfadiazine