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Phendimetrazine

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Phendimetrazine tartrate, is an FDA approved, schedule II prescription weight loss medication to treat obesity.

How does it work?

Phendimetrazine tartrate is an amphetamine, similar to Phentermine but has shorter duration, and a bit more potential for habit forming compared to Phentermine. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Classification

Drugs of this class used in obesity are commonly known as "anorectics" or "anorexigenics".

Weight loss

Adult obese subjects instructed in dietary management and treated with anorectic drugs, lose more weight on the average than those treated with placebo and diet, as determined in relatively short term clinical trials. The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a fraction of a pound a week. The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks.

Indications and usage

Phendimetrazine tartrate extended-release capsules are indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia) who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

Contraindications

History of cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension, pulmonary hypertension) During or within 14 days following the administration of monoamine oxidase inhibitors

  • Hyperthyroidism
  • Glaucoma
  • Agitated states
  • History of drug abuse
  • Pregnancy (see Precautions, Pregnancy)
  • Nursing
  • Known hypersensitivity or idiosyncratic reactions to sympathomimetics

Dosage

Extended-release capsule Since the product is an extended-release dosage form, limit to one extended-release capsule (105 mg phendimetrazine tartrate) in the morning (30 to 60 minutes before morning meal). Each extended-release capsule contains 105 mg phendimetrazine tartrate in a Brown/Clear capsule imprinted E 5254.

How is it supplied?

Packed in bottles of 100 and 1000 capsules. Store at 20° to 25°C (68° to 77°F)

Latest research - Phendimetrazine

PubMed
Clinical trials


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