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Aducanumab

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Aducanumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
Targetbeta amyloid
Clinical data
Other namesBIIB037
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
KEGG
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC6472H10028N1740O2014S46
Molar mass145.9 kg/mol g·mol−1

Aducanumab is a human monoclonal antibody that was studied for the treatment of Alzheimer's disease (AD).[1] It was developed by Biogen Inc., which licensed the drug candidate from Neurimmune, its discoverer.[2] The antibody targets aggregated forms of β-amyloid found in the brains of people with Alzheimer’s disease, in the hopes of reducing its buildup.[3] Biogen halted development of the drug in March 2019 after preliminary data from two phase III trials suggested it would not meet the primary endpoint.[4][5][6]

Research

Interim results from the second Phase 1 study of the drug were reported in March 2015.[1][7]

A phase 1b study was published in August 2016, based on one year of "monthly intravenous infusions" of aducanumab, with brain scans to measure amyloid plaques.[8] Phase 3 clinical trials were ongoing in September 2016,[8] but were canceled in March 2019 after "an independent group's analysis show[ed] that the trials were unlikely to 'meet their primary endpoint.'"[9]

References


 

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