Almokalant
Almokalant
Almokalant (pronunciation: al-mo-ka-lant) is a class III antiarrhythmic agent used in the treatment of cardiac arrhythmia. It is a potassium channel blocker that works by prolonging the duration of the action potential, thereby delaying repolarization and refractoriness.
Etymology
The term "Almokalant" is derived from the chemical name of the drug, which is 4-(4-aminobenzoyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-5-quinazolinamine. The name is a combination of parts of the chemical name, although the exact origin is not known.
Pharmacology
Almokalant works by blocking the potassium channels in the heart, which are responsible for repolarizing the heart muscle after each beat. This prolongs the duration of the action potential, which in turn delays the refractory period. This delay allows the heart more time to fill with blood before the next contraction, which can help to regulate the heart's rhythm.
Related Terms
- Antiarrhythmic agent: A drug used to suppress abnormal rhythms of the heart, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
- Potassium channel: A type of ion channel that allows potassium to pass through the cell membrane in accordance with its electrochemical gradient.
- Cardiac arrhythmia: A group of conditions in which the heartbeat is irregular, too fast, or too slow.
- Action potential: A short-lasting event in which the electrical membrane potential of a cell rapidly rises and falls, following a consistent trajectory.
External links
- Medical encyclopedia article on Almokalant
- Wikipedia's article - Almokalant
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