Amitriptyline

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Information about Amitriptyline

Amitriptyline is a tricyclic antidepressant that is widely used in the therapy of depression.

Liver safety of Amitriptyline

Amitriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.

Mechanism of action of Amitriptyline

Amitriptyline (am" i trip' ti leen) is a tricyclic antidepressant which is believed to act by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters.

Clinical use of Amitriptyline

Amitriptyline is indicated for therapy of depression and was approved for this indication in the United States in 1961, and is still widely used, with more than 10 million prescriptions for amitriptyline being filled yearly. Amitriptyline is also used for anorexia and bulimia and for adjunctive treatment of neurogenic pain.

Dosage and administration for Amitriptyline

Amitriptyline is available in generic forms and under the brand name of Elavil in 10, 25, 50, 75, 100 and 150 mg tablets. The typical recommended dose for depression in adults is 75 to 100 mg daily in divided doses, increasing gradually to a maximum of 300 mg daily. Amitriptyline can also be given as a single nighttime dose of 50 to 150 mg.

Side effects of Amitriptyline

Common side effects include dizziness, headache, drowsiness, restlessness, confusion, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


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