Amitriptyline
Amitriptyline
Amitriptyline (pronounced: a-mi-TRIP-ti-leen) is a tricyclic antidepressant (TCA) used in the treatment of various forms of depression, neuropathic pain, and migraine prophylaxis.
Etymology
The term "Amitriptyline" is derived from its chemical structure, which consists of three rings of atoms (hence the term "tricyclic"). The prefix "Amitri-" is derived from the Greek word "amitros", meaning "without rivalry", and "-tyline" is a common suffix used in the names of tricyclic antidepressants.
Usage
Amitriptyline is primarily used to treat major depressive disorder and other types of depression. It is also used off-label for the treatment of certain types of chronic pain, including neuropathic pain and fibromyalgia. In addition, it is sometimes used as a preventive treatment for migraine.
Mechanism of Action
Amitriptyline works by inhibiting the reuptake of certain neurotransmitters, specifically serotonin and norepinephrine, in the brain. This increases the levels of these neurotransmitters in the brain, which can help to improve mood and reduce pain.
Side Effects
Common side effects of amitriptyline include dry mouth, drowsiness, constipation, and blurred vision. More serious side effects can include heart problems, seizures, and an increased risk of suicidal thoughts and behaviors.
Related Terms
External links
- Medical encyclopedia article on Amitriptyline
- Wikipedia's article - Amitriptyline
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