Amphotericin B

From WikiMD

amphotericin B (AM-fuh-TAYR-ih-sin ...) is a drug used in the treatment of infections caused by fungi. It is a type of antifungal.

Information about Amphotericin B

Amphotericin B is an antifungal agent with a broad spectrum of activity against many fungal species.

Liver safety of Amphotericin B

Amphotericin B commonly causes mild to moderate serum aminotransferase elevations and can cause hyperbilirubinemia, but acute, clinically apparent drug induced liver injury from amphotericin B therapy is exceedingly rare.

Mechanism of action of Amphotericin B

Amphotericin (am" foe ter' i sin) B is a polyene macrolide antibiotic that acts by binding to sterols in the plasma membranes of fungi causing the cells to leak, eventually leading to fungal cell death. Amphotericin B is indicated for the treatment of a several fungal and other infections including leishmanias, invasive aspergillosis, blastomycosis, ppcandidiasis]], coccidiomycosis, cryptococcal meningitis, cryptococcosis, histoplasmosis, mucormycosis, sporotrichosis, and others.

FDA approval information for Amphotericin B

Amphotericin B was approved by the FDA in 1971 and is currently widely used in the treatment of serious fungal infections. Amphotericin B is insoluble in water and is formulated for intravenous use by complexing it with lipotrophic molecules such as deoxycholate, liposomes or lipid complexes.

Brand name for Amphotericin B

Amphotericin is available in multiple forms and concentrations generically and under the brand names Amphocin and Fungizone (deoxycholate), Ambisome (liposome), Abelcet (lipid complex), and Amphotec (cholesteryl sulfate complex).

Dosage and administration for Amphotericin B

The recommended dose varies by drug form and by disease entity; amphotericin B is given intravenously and the usually dosage is up 0.5 to 1.0 mg/kg daily. Many fungal infections require prolonged therapy (for 1 month to as many as 9 months).

Side effects of Amphotericin B

Common side effects include fever and chills, nausea, weight loss, headache, malaise, azotemia, hypokalemia, anemia, renal tubular acidosis and phlebitis at peripheral vein infusion sites.


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