From WikiMD

This page contains changes which are not marked for translation.

Other languages:

Dr Prab R Tumpati, MD

Editor-In-Chief: Prab R. Tumpati M.D.. Founder, WikiMD and W8MD Weight Loss, Sleep and MedSpa Centers. Dr. Tumpati is board certified physician practicing sleep medicine, obesity medicine, aesthetic medicine and internal medicine. Dr. Tumpati’s passion is prevention rather than cure. As a physician with fellowship training in Obesity Medicine, Dr. Tumpati has a unique approach to wellness, weight loss, aesthetics with a focus on prevention rather than cure. Dr. Tumpati believes in educating the public on the true science and art of medicine, nutrition, wellness and beauty.

WikiMD Resources for Anencephaly


Most recent articles on Anencephaly

Most cited articles on Anencephaly

Review articles on Anencephaly

Articles on Anencephaly in N Eng J Med, Lancet, BMJ


Powerpoint slides on Anencephaly

Images of Anencephaly

Photos of Anencephaly

Podcasts & MP3s on Anencephaly

Videos on Anencephaly

Evidence Based Medicine

Cochrane Collaboration on Anencephaly

Bandolier on Anencephaly

TRIP on Anencephaly

Clinical Trials

Ongoing Trials on Anencephaly at Clinical

Trial results on Anencephaly

Clinical Trials on Anencephaly at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Anencephaly

NICE Guidance on Anencephaly


FDA on Anencephaly

CDC on Anencephaly


Books on Anencephaly


Anencephaly in the news

Be alerted to news on Anencephaly

News trends on Anencephaly


Blogs on Anencephaly


Definitions of Anencephaly

Patient Resources / Community

Patient resources on Anencephaly

Discussion groups on Anencephaly

Patient Handouts on Anencephaly

Directions to Hospitals Treating Anencephaly

Risk calculators and risk factors for Anencephaly

Healthcare Provider Resources

Symptoms of Anencephaly

Causes & Risk Factors for Anencephaly

Diagnostic studies for Anencephaly

Treatment of Anencephaly

Continuing Medical Education (CME)

CME Programs on Anencephaly


Anencephaly en Espanol

Anencephaly en Francais


Anencephaly in the Marketplace

Patents on Anencephaly

Experimental / Informatics

List of terms related to Anencephaly

Anencephaly is a cephalic disorder that results from a neural tube defect that occurs when the cephalic (head) end of the neural tube fails to close, usually between the 23rd and 26th day of pregnancy, resulting in the absence of a major portion of the brain, skull, and scalp. Infants with this disorder are born without a forebrain - the largest part of the brain consisting mainly of the cerebrum - which is responsible for thinking and coordination. The remaining brain tissue is often exposed - not covered by bone or skin.


Infants born with anencephaly are usually blind, deaf, unconscious, and unable to feel pain. Although some individuals with anencephaly may be born with a rudimentary brainstem, which controls autonomic and regulatory function, the lack of a functioning cerebrum permanently rules out the possibility of ever gaining consciousness. Reflex actions such as respiration (breathing) and responses to sound or touch may occur. The disorder is one of the most common disorders of the fetal central nervous system.


Most of the people who suffer of anencephaly die in the womb of their mother, during childbirth or in the next few hours after the have exited the mother's body. Although in some cases, it has been known that certain babies have lasted a week and a half, and the current record of lifespan is of twelve years.


There is no cure or standard treatment for anencephaly and the prognosis for affected individuals is poor. Most anencephalic babies do not survive birth. If the infant is not stillborn, then he or she will usually die within a few hours or days after birth. Anencephaly can often be diagnosed before birth through an ultrasound examination. The maternal serum alpha-fetoprotein (AFP screening) and detailed fetal ultrasound can be useful for screening for neural tube defects such as spina bifida or anencephaly.

In almost all cases anencephalic infants are not aggressively resuscitated since there is no chance of the infant ever achieving a conscious existence. Instead, the usual clinical practice is to offer hydration, nutrition and comfort measures and to "let nature take its course". Artificial ventilation, surgery (to fix any co-existing congenital defects), and drug therapy (such as antibiotics) are usually regarded as being pointless. Some clinicians see no point in even providing nutrition and hydration, arguing that euthanasia is morally and clinically appropriate in such cases.

Rate of occurrence

In the United States, approximately 1,000 to 2,000 babies are born with anencephaly each year. Female babies are more likely to be affected by the disorder. About 95% of women who learn that they will have an anencephalic baby choose to have an abortion. Of the remaining 5%, about 55% are stillborn. The rest usually live only a few hours or days.


The cause of anencephaly is unknown. Neural tube defects do not follow direct patterns of heredity. Studies show that a woman who has had one child with a neural tube defect such as anencephaly, has about a 3% risk to have another child with a neural tube defect. This risk can be reduced to about 1% if the woman takes high dose (4mg/day) folic acid before and during pregnancy.

It is known that women taking certain medication for epilepsy and women with insulin dependent diabetes have a higher chance of having a child with a neural tube defect. Genetic counseling is usually offered to women at a higher risk of having a child with a neural tube defect to discuss available testing.

Recent studies have shown that the addition of folic acid to the diet of women of child-bearing age may significantly reduce, although not eliminate, the incidence of neural tube defects. Therefore, it is recommended that all women of child-bearing age consume 0.4 mg of folic acid daily, especially those attempting to conceive or who may possibly conceive. It is foolhardy to wait until pregnancy has begun, since by the time a woman knows she is pregnant, the critical time for the formation of a neural tube defect has usually already passed. A physician may prescribe even higher dosages of folic acid (4 mg/day) for women who have had a previous pregnancy with a neural tube defect.

External links

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Other languages:

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="">Anencephaly</a>

  • Individual results may vary for weight loss from our sponsors.