Anti-smith antibody

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Anti-Smith Antibody

The Anti-Smith Antibody (pronounced: an-tee-smith an-ti-bod-ee) is a specific type of autoantibody that is often associated with Systemic Lupus Erythematosus (SLE). The term "Anti-Smith" is derived from the patient's name in whom the antibody was first discovered.

Definition

Anti-Smith Antibodies are autoantibodies that target proteins found in the nucleus of a cell. These proteins, known as Smith (Sm) proteins, are commonly found in patients with SLE. The presence of Anti-Smith Antibodies is a significant marker for this disease.

Clinical Significance

Anti-Smith Antibodies are highly specific for SLE, and are rarely found in other autoimmune diseases. They are present in approximately 30% of SLE patients. The presence of these antibodies, along with other clinical and laboratory findings, can aid in the diagnosis of SLE.

Testing

Testing for Anti-Smith Antibodies is typically done through a blood test. This test is often part of a panel of tests used to diagnose SLE. Other tests in this panel may include Antinuclear Antibody (ANA) test, Anti-dsDNA test, and Complement levels.

Treatment

Treatment for patients with Anti-Smith Antibodies is focused on managing the symptoms of SLE. This may include medications to reduce inflammation and suppress the immune system, such as Corticosteroids and Immunosuppressants.

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