Anticoagulants

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Anticoagulants is drugs used to stop abnormal blood clotting, such as to prevent stroke.

Information about Anticoagulants

Antithrombotic agents are separated into those drugs that decrease the synthesis of coagulation factors or interrupt the coagulation cascade (Anticoagulants) and those that inhibit platelet function (antiplatelet agents).  A third class of agents are the thrombolytic drugs which act to promote dissolution of thromboses after they have formed.  The antithrombotic agents are rare causes of clinically apparent acute liver injury.


Anticoagulants are used largely for the prevention and treatment of venous thromboses, although they have some activity against arterial thromboses.  Their major clinical use is prevention and treatment of deep vein thrombosis in high risk persons (such as after hip or knee replacement surgery or with prolonged immobilization), prevention and treatment of pulmonary embolism, and prevention of arterial embolism in patients with atrial fibrillation.


The anticoagulant agents in clinical use and their year of approval include heparin and its low molecular weight derivatives dalteparin (Fragmin: 1994), enoxaparin (Lovenox: 1993), and tinzaparin (Innohep: 2000); direct thrombin inhibitors such as dabigatran (Pradaxa: 2010) and desirudin (Iprivask: 2003); factor Xa inhibitors such as fondaparinux (Arixtra: 2001), rivaroxaban (Xarelto: 2011), apixaban (Eliquis: 2012) and edoxaban (Savaysa: 2015), and warfarin (Coumadin: 1967), a vitamin K antagonist.

List of antithrombotic agents

Heparins

Warfarin

Antiplatelet agents

Miscellaneous

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