Doctor in scrubs


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
14,007 pages, 4,159,090 edits & 43,392,504 views.

Free unbiased diet, health and wellness info!

Asparaginase

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

asparaginase (as-PAYR-uh-jih-NAYS) is a drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli) . It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. Also called Elspar and L-asparaginase.


Information about Asparaginase

Asparaginase is a bacterial enzyme that is used as an antineoplastic agent, largely in the therapy of acute lymphocytic leukemia

Liver safety of Asparaginase

L-asparaginase has many side effects, one of which is hepatic injury that is characterized by inhibition of hepatic protein synthesis and steatosis, which can be severe and lead to death from hepatic failure. 

Mechanism of action of Asparaginase

Asparaginase (as par' a jin ase), often referred to as L-asparaginase, is a bacterial enzyme that acts to decrease tissue stores of asparagine, a secondary amino acid that is important in the growth of many cancers.  Asparaginase, prepared from E. coli, was introduced into cancer chemotherapy over 50 years ago and remains an important agent in the therapy of acute lymphocytic leukemia.  Asparaginase has activity against other cancer types, but is rarely used for other indications. 

FDA approval information for Asparaginase

Asparaginase was first approved for use in the United States in 1972 as an anticancer agent, with initial preparations being prepared from E. coli.  Pegylated formulations of E. coli-derived asparaginase (pegaspargase) became available and were approved for use in 1994.  These preparations can be given every other week and have largely replaced standard asparaginase.  Asparaginase made from other bacteria (Erwinia chrysanthemi) was approved for use in the United States in 2011 and is available under the brand name Erwinaze. 

Dosage and administration for Asparaginase

Standard asparaginase is given either by intramuscular injection or, more typically, intravenous injection in doses of 25,000 IU/m2 three times weekly in 14 day cycles.  Pegaspargase can also be given intramuscularly or intravenously, typically in a dose of 2500 IU/m2 every other week.  Both standard and pegylated asparaginase are usually given in combination with other antineoplastic agents such as vincristine, mercaptopurine, methotrexate, daunorubicin, and prednisone. 

Side effects of Asparaginase

Asparaginase has many dose related toxicities including nausea, fever, hypersensitivity reactions (urticaria, wheezing), clotting abnormalities, bone marrow suppression, pancreatitis, hepatotoxicity and central nervous system toxicities.    Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Asparaginase

Reviews for Asparaginase

Learn more about Asparaginase

Latest research - Asparaginase

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Asparaginase is a stub. If you are familiar with the topic Asparaginase, you can help us. Paid editors welcome!

 

Asparaginase is part of WikiMD's free ^articles!

^Asparaginase (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available