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Information about Atorvastatin

Atorvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury.

Mechanism of action of Atorvastatin

Atorvastatin (a tor" va stat' in) is a potent, orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. Like other members of its class (the “statins”), atorvastatin lowers total serum cholesterol and low density lipoprotein (LDL) concentrations, thereby reducing the risk of atherosclerosis and its complications – myocardial infarction and stroke. Atorvastatin

FDA approval information for Atorvastatin

Atorvastatin was approved for use in the United States in 1996 and has become one of the most commonly prescribed drugs in America, with more than 50 million prescriptions filled yearly. The current primary indication for atorvastatin is the treatment of hypercholesterolemia in persons at high risk for coronary, cerebrovascular and peripheral artery disease.

Brand name for Atorvastatin

Atorvastatin is available in tablets of 10, 20, 40 and 80 mg generically and under the trade name Lipitor, and is also available in combination with other cardiovascular agents such as amlodipine (Caduet).

Dosage and administration for Atorvastatin

The recommended dose is 10 to 80 mg once daily based upon tolerability and lipid levels. Common side effects include muscle cramps, joint aches, headache, dyspepsia and weakness, symptoms that occur with all of the currently available statins.

Also see Lipitor

Lipid lowering medications

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