Bcl-2
Bcl-2 (pronounced as "Bee-see-ell-two") is a family of proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. Bcl-2 is specifically considered an important anti-apoptotic protein and is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
Etymology
The term "Bcl-2" is an acronym for B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas.
Function
Bcl-2 proteins are critical for cell survival and can be found on the outer membrane of mitochondria, where they prevent the release of certain proteins that trigger cell death. They are also found on the membranes of the endoplasmic reticulum and nuclear envelope.
Related Terms
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms.
- Mitochondria: A double-membraned organelle found in most eukaryotic organisms.
- Endoplasmic reticulum: A type of organelle in the cells of eukaryotic organisms that forms an interconnected network of flattened, membrane-enclosed sacs or tubes known as cisternae.
- Nuclear envelope: A double lipid bilayer that encloses the genetic material in eukaryotic cells.
See Also
External links
- Medical encyclopedia article on Bcl-2
- Wikipedia's article - Bcl-2
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