BerEp4

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BerEp4

BerEp4 (pronounced: /bɛrɛpˈfɔːr/) is a monoclonal antibody that is used as a diagnostic tool in pathology. It is primarily used to identify cells of epithelial origin, particularly in the context of cancer diagnosis.

Etymology

The term "BerEp4" is derived from the location where the antibody was first developed, Berlin, and "Ep4" refers to the specific clone of the antibody.

Usage

BerEp4 is used in immunohistochemistry to identify cells of epithelial origin. It is particularly useful in distinguishing between adenocarcinoma and mesothelioma, as it is typically positive in the former and negative in the latter. This makes it a valuable tool in the diagnosis of lung cancer and other malignancies of epithelial origin.

Related Terms

  • Monoclonal antibody: A type of protein made in the laboratory that can bind to substances in the body, including cancer cells.
  • Pathology: The scientific study of disease.
  • Epithelial: Referring to the cells that line the surfaces of the body.
  • Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.
  • Immunohistochemistry: A process in which antibodies are used to detect proteins in cells of a tissue section.
  • Adenocarcinoma: A type of cancer that starts in the mucous glands inside of organs.
  • Mesothelioma: A type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium).

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