Bile acid resins/sequestrants

From WikiMD
Jump to navigation Jump to search

Information about Bile acid resins/sequestrants

The bile acid resins or sequestrants are the oldest and safest lipid lowering agents, but are less potent than other classes now available and are not always well tolerated.

Mechanism of action of Bile acid resins/sequestrants

The bile acid sequestrants are highly positively charged molecules that bind to the negatively charged bile acids in the intestine, inhibiting their lipid solubilizing activity and thus blocking cholesterol absorption. They also inhibit the reabsorption of bile acids (which is typically 95%) and thus cause a contraction of the bile acid pool which leads to increased bile acid synthesis that competes with cholesterol synthesis in the liver, which also contributes to the lowering of serum cholesterol levels.

FDA approval information for Bile acid resins/sequestrants

Three bile acid sequestrants are available in the United States (common brand name and year of approval): cholestyramine (Questran, 1973), colesevelam (Welchol, 2000) and colestipol (Colestid, 1977). These agents are also used for therapy of pruritus for their activity in lowering the “pruritogens” that accumulate in cholestatic forms of liver disease.

Liver safety of Bile acid resins/sequestrants

The bile acid resins are not absorbed and thus have not been linked to clinically apparent drug induced liver injury. They have the potential to bind to vitamins, hormones or medications in the intestine and result in subtherapeutic serum levels.

The bile acid resins have not been associated with clinically apparent acute liver injury, which is probably because of their lack of absorption. For unexplained reasons, however, therapy with these agents is associated with a low rate of mild (1 to 3 fold) serum aminotransferase and alkaline phosphatase elevations which are self-limited and not associated with symptoms or jaundice and resolve rapidly with stopping therapy.

Lipid lowering medications

Cost and Coupons - Bile acid resins/sequestrants

Reviews for Bile acid resins/sequestrants

Wellness that matters!

Articles on Bile acid resins/sequestrants

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Bile acid resins/sequestrants

Drug classes

WikiMD Resources for Bile acid resins/sequestrants


Most recent articles

Most cited

Review articles

Articles on Bile acid resins/sequestrants in N Eng J Med, Lancet, BMJ

Media Bile acid resins/sequestrants

Powerpoint slides

Podcasts and MP3's


Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Bile acid resins/sequestrants

Trial results on Bile acid resins/sequestrants

Clinical Trials on Bile acid resins/sequestrants at Google

Books and news

Books on Bile acid resins/sequestrants

Bile acid resins/sequestrants in the news

Commentary Bile acid resins/sequestrants

Blogs on Bile acid resins/sequestrants

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

YouTube videos

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss* program can HELP | Advertise on WikiMD

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary.