Bleselumab

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Bleselumab

Bleselumab (pronounced: bleh-seh-loo-mab) is a monoclonal antibody used in the field of transplantation medicine. It is designed to prevent organ rejection, particularly in kidney transplant patients.

Etymology

The name "Bleselumab" follows the INN naming convention for monoclonal antibodies. The "-lumab" suffix indicates that it is a human antibody, while the "bese-" stem is used for immunomodulating antibodies.

Mechanism of Action

Bleselumab works by binding to the interleukin-2 receptor on the surface of T cells, thereby inhibiting the activation and proliferation of these cells. This helps to prevent the immune response that can lead to organ rejection.

Related Terms

  • Monoclonal antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
  • Transplantation medicine: The field of medicine that studies and manages the process of transferring cells, tissues, or organs from one person to another to restore function and health.
  • Kidney transplant: A surgical procedure to place a healthy kidney from a live or deceased donor into a person whose kidneys no longer function properly.
  • Interleukin-2 receptor: A type of protein found on the surface of certain immune cells, including T cells, that plays a role in activating the immune response.
  • T cells: A type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens.

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