Brunner syndrome
Brunner Syndrome
Brunner Syndrome (pronounced: broo-ner sin-drome) is a rare genetic disorder that is characterized by aggressive behavior, mild intellectual disability, and abnormal behaviors, particularly in males. The syndrome is named after Hans Brunner, a Dutch human geneticist who first described the condition.
Etymology
The term "Brunner Syndrome" is derived from the name of the Dutch human geneticist, Hans Brunner, who first described the condition in 1993. The term "syndrome" is derived from the Greek word "syndromē", which means "concurrence of symptoms, concourse".
Symptoms
The primary symptoms of Brunner Syndrome include aggressive behavior, mild intellectual disability, and abnormal behaviors. These may include impulsivity, signs of hyperactivity, and physical aggression. The severity of these symptoms can vary widely among affected individuals.
Causes
Brunner Syndrome is caused by mutations in the MAOA gene. This gene provides instructions for making an enzyme called monoamine oxidase A, which is responsible for breaking down certain chemicals in the brain. Mutations in the MAOA gene lead to reduced activity of this enzyme, which can result in abnormal behaviors.
Diagnosis
Diagnosis of Brunner Syndrome is based on the presence of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests. Genetic testing can confirm a diagnosis.
Treatment
Treatment of Brunner Syndrome is directed toward the specific symptoms that are apparent in each individual. This may include behavioral therapy, medication, and other supportive measures.
Related Terms
External links
- Medical encyclopedia article on Brunner syndrome
- Wikipedia's article - Brunner syndrome
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