Buccal administration

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Buccal Administration

Buccal administration (pronounced: buk-uhl ad-min-uh-strey-shuhn) is a method of administering medication via the buccal mucosa (the lining of the cheek and area between the gums and upper and lower lips).

Etymology

The term "buccal" comes from the Latin word "bucca," which means cheek. "Administration" is derived from the Latin word "administratio," meaning management or control.

Definition

Buccal administration involves placing a drug between the gums and cheek, where it dissolves and is absorbed into the blood vessels. This method bypasses the first-pass metabolism, allowing for a higher bioavailability of the drug and faster onset of action.

Related Terms

  • Sublingual Administration: A similar method of drug administration where the drug is placed under the tongue.
  • Oral Administration: The most common method of drug administration, where the drug is swallowed and absorbed in the digestive tract.
  • First-pass Metabolism: The process where a drug is metabolized in the liver before it reaches systemic circulation.
  • Bioavailability: The proportion of a drug that enters circulation when introduced into the body and so is able to have an active effect.

Advantages and Disadvantages

Buccal administration has several advantages, including ease of use, rapid onset of action, and avoidance of first-pass metabolism. However, it also has some disadvantages, such as potential irritation to the buccal mucosa and limited use to certain types of drugs.

Applications

Buccal administration is often used for drugs that are unstable in the stomach or poorly absorbed in the digestive tract. It is also used for local treatment of conditions in the mouth, such as fungal infections.

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