Bucindolol
Bucindolol (pronounced boo-sin-doe-lol) is a non-selective Beta blocker used in the treatment of hypertension and heart failure. It is a synthetic, beta-adrenergic receptor blocking agent, chemically classified as an aryloxypropanolamine derivative.
Etymology
The term "Bucindolol" is derived from the chemical name "1-(tert-butylamino)-3-[[2-(cyclopropylmethoxy)ethyl]phenoxy]-2-propanol". The prefix "Bucin-" is derived from "butyl" and "cyclopropyl", the two chemical groups present in the molecule. The suffix "-olol" is a common ending for beta blockers, indicating its function.
Pharmacology
Bucindolol is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 adrenergic receptors. This results in a decrease in heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Bucindolol also has mild vasodilating properties, which are thought to be due to its intrinsic sympathomimetic activity.
Clinical Use
Bucindolol is used in the treatment of hypertension and heart failure. It is also used off-label for the treatment of arrhythmias and angina pectoris.
Side Effects
Common side effects of Bucindolol include fatigue, dizziness, and shortness of breath. Less common side effects can include bradycardia, hypotension, and bronchospasm.
Related Terms
External links
- Medical encyclopedia article on Bucindolol
- Wikipedia's article - Bucindolol
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