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Template:Blacklisted-links CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) is a trial currently underway in the U.S. to study the effects of prolonged calorie restriction on healthy human subjects.

The CALERIE study is being carried out at the Pennington Biomedical Research Center (Baton Rouge, Louisiana), the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Boston, Massachusetts) and the Washington University School of Medicine (St. Louis, Missouri).[1] It is hoped that caloric restriction reduces the incidence of cardiovascular disease and cancer and leads to a longer life, as has been demonstrated previously in numerous animal studies.[2] CALERIE is the first study to investigate prolonged calorie restriction in healthy humans, which is practiced and advocated for by the members of the Calorie Restriction Society. Study subjects are selected from people who are not obese (because calorie restriction on obese people is already known to lengthen life, but possibly for different reasons).[3]

A smaller predecessor study ended in 2006. Forty-eight subjects were randomly assigned to a control group and a treatment group; those in the treatment group were put on a 25% calorie reduction over a 6-month period. It was found that the treatment group had lower insulin resistance, lower levels of LDL cholesterol, lower body temperature and blood-insulin levels as well as less oxidative damage to their DNA.[3]

The second, larger, phase of CALERIE begain in 2007. The participants are subjected to a 25% calorie restriction over a 2-year period, and several physiological variables are regularly monitored. Participants are paid $5,000 at Tufts and Pennington and $2,400 at Washington University. As of October 2009, the study had 132 participants and was still accepting new ones.[2]

Study subjects have to be highly motivated and organized enough to keep a detailed journal of all foods they eat. Their daily baseline calorie requirements are precisely determined before the trial: in a two-week laboratory test the rate of carbon dioxide production is measured, allowing to compute the number of burned calories. The subjects are then taught a diet of low-energy density foods, such as vegetables, fruits (especially apples), insoluble fiber and soups. Most subjects reported that they felt hungry for the first few weeks, after which they adjusted to the new diet. Complaints focused on the rigid bookkeeping scheme imposed on them.[2]



Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity

External links

  • About CALERIE, retrieved 12 October 2009.
  • 2.0 2.1 2.2 Gertner, Jon (2009-10-07). "The Calorie-Restriction Experiment". The New York Times Magazine.
  • 3.0 3.1 Eat less, live more, The Economist, April 22, 2006
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