CRLF1

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CRLF1

CRLF1 (pronounced as C-R-L-F-One), also known as Cytokine Receptor-Like Factor 1, is a protein that in humans is encoded by the CRLF1 gene.

Etymology

The term CRLF1 is an abbreviation derived from the term Cytokine Receptor-Like Factor 1. The term 'Cytokine' is derived from the Greek words 'cyto-' meaning 'cell' and '-kinos' meaning 'movement'. 'Receptor' refers to a protein molecule that receives chemical signals from outside a cell. 'Like' is used to indicate similarity or comparison. 'Factor' is a substance that in humans is necessary for a biochemical reaction or process. '1' indicates that it is the first of its kind or series.

Function

CRLF1 is a member of the Cytokine receptor family. The encoded protein is a secreted glycoprotein, forming a heterodimeric complex with Cardiotrophin-like cytokine factor 1, which mediates cell survival, cell proliferation, and cell differentiation. Mutations in this gene have been associated with Cold-induced sweating syndrome.

Related Terms

  • Cytokine receptor: A large family of proteins that are involved in signaling between cells during immune responses and cell growth.
  • Cardiotrophin-like cytokine factor 1: A protein that in humans is encoded by the CLCF1 gene. It is known to form a heterodimeric complex with CRLF1.
  • Cell survival: The avoidance of apoptosis (programmed cell death) by a cell.
  • Cell proliferation: The process that results in an increase of the number of cells, and is defined by the balance between cell divisions and cell loss through cell death or differentiation.
  • Cell differentiation: The process by which a less specialized cell becomes a more specialized cell type.
  • Cold-induced sweating syndrome: A condition characterized by problems with regulating body temperature and other abnormalities.

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