From WikiMD
Jump to navigation Jump to search

CYT006-AngQb was an investigational vaccine against angiotensin II, designed to lower blood pressure. It was somewhat effective in clinical trials, but less so than conventional drugs against hypertension (elevated blood pressure).[1]

Method of action

Angiotensin II causes blood vessels to constrict, and drives blood pressure up. CYT006-AngQb consists of virus-like particles covalently coupled to angiotensin II. Subcutaneous injection causes the immune system to produce antibodies which reduce angiotensin II blood levels, lowering blood pressure.


In a 2008 phase IIa study, 72 patients received 100 µg, 300 µg or placebo in weeks 0, 4, and 12. Blood pressure was lowered dose-dependently, by 5.6 mmHg (systolic) and 2.8 mmHg (diastolic) in the 300 µg group. Morning blood pressure (8:00) was lowered by 25 mmHg (systolic) and 13 mmHg (diastolic).

Side effects were mild and included local reactions, headache and fatigue.[2]

The 2008 trial was small and exploratory. It did not address the question of whether the vaccine actually protects internal organs, nor did it address safety concerns such as whether the vaccine would cause autoimmune disease. If a standard drug treatment is found to dangerously inhibit the renin-angiotensin-aldosterone system, it can be withdrawn and the effects reversed quickly, but that would not be true of the vaccine. However, poor compliance to standard treatment is the main reason for inadequate control of blood pressure, and if vaccination were safe and effective in the long run, it may solve many compliance problems.[3]

CYT006-AngQb did not reach Phase III studies because the antihypertensive effects were small compared to existing ACE inhibitors and angiotensin II receptor antagonists, and they were not reproducible across dosing schemes. Similar vaccines with modified immunogens and different adjuvants are being investigated.[1][4]


  1. 1.0 1.1 Brown, MJ (2009). "Success and failure of vaccines against renin-angiotensin system components". Nature Reviews Cardiology. 6 (10): 639–47. doi:10.1038/nrcardio.2009.156. PMID 19707182.
  2. Tissot AC, Maurer P, Nussberger J; et al. (2008). "Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study". Lancet. 371 (9615): 821–7. doi:10.1016/S0140-6736(08)60381-5. PMID 18328929. Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  3. Samuelsson O, Herlitz H (2008). "Vaccination against high blood pressure: a new strategy". Lancet. 371 (9615): 788–9. doi:10.1016/S0140-6736(08)60355-4. PMID 18328909.
  4. Do, TH; Chen, Y; Nguyen, VT; Phisitkul, S (2010). "Vaccines in the management of hypertension". Expert opinion on biological therapy. 10 (7): 1077–87. doi:10.1517/14712598.2010.487060. PMID 20455790.

Modified from Wikipedia's article licensed under GNU FDL

Glossaries and dictionaries | Medicine portal | Health Topics | Health Encyclopedia | First Aid | Weight Loss | Drugs | Glossary of medicine | insurance | Glossary of health topics | Drug classes | Medicines | Dentistry portal | Medications portal | Pharmacology portal | Psychiatry portal | Rare diseases | List of health topics

Health science - Medicine - Rare diseases - List of patient cases
Anesthesiology - Dermatology - Emergency Medicine - General practice - Intensive care medicine - Internal medicine - Neurology - Obstetrics & Gynecology - Pediatrics - Podiatry - Public Health & Occupational Medicine - Psychiatry - Radiology - Surgery
Branches of Internal medicine
Cardiology - Endocrinology - Gastroenterology - Hematology - Infectious diseases - Nephrology - Oncology - Pulmonology - Rheumatology
Branches of Surgery
General surgery - Cardiothoracic surgery - Neurosurgery - Ophthalmology - Orthopedic surgery - Otolaryngology (ENT) - Plastic surgery - Podiatric surgery - Urology - Vascular surgery
A-Z health topics | Popular health topics | Lab tests
Endocrine words

A |  B |  C |  D |  E |  F |  G |  H |  I |  J |  K |  L |  M | N |  O |  P |  Q |  R |  S |  T |  U |  V |  W |  X |  Y |  Z

Glossary of medical terms | Dictionary of medicine | Drugs A-Z | Topics in Medicine | Dictionary of drugs

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*
Wellness | weight loss portal | Weight loss tips | W8MD's medical weight loss | Lose weight New York City

Philadelphia weight loss | Lose weight King of Prussia | Weight Loss NYC | Brooklyn weight loss | Advertise

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="">CYT006-AngQb</a>

  • Individual results may vary for weight loss from our sponsors.