Cabot rings

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Cabot rings (pronounced: ka-bot) are thin, thread-like inclusion bodies seen in the red blood cells under certain pathological conditions. They are named after the American physician Richard Clarke Cabot who first described them in 1903.

Etymology

The term "Cabot rings" is derived from the name of Richard Clarke Cabot, an American physician who first described these structures. Cabot was a pioneer in the field of internal medicine and made significant contributions to the understanding of blood diseases.

Description

Cabot rings are thin, red-violet, thread-like or ring-like structures that can be seen in the red blood cells under a microscope. They are usually found in conditions where there is an abnormality in the formation of red blood cells, such as pernicious anemia, lead poisoning, and some cases of thalassemia.

Formation

The exact mechanism of the formation of Cabot rings is not fully understood. However, it is believed that they are remnants of the mitotic spindle, which is a structure that helps in the division of cells. In conditions where there is an abnormality in the formation of red blood cells, these remnants may not be completely removed and can be seen as Cabot rings.

Clinical significance

The presence of Cabot rings in the red blood cells is a sign of certain pathological conditions. They are most commonly seen in pernicious anemia, a condition where the body is unable to absorb vitamin B12 from the diet, leading to a deficiency. They can also be seen in lead poisoning and some cases of thalassemia, a group of inherited blood disorders.

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