Cabozantinib
Contents
Information about Cabozantinib
Cabozantinib is orally available kinase inhibitor and antineoplastic agent that is used in treatment of advanced, metastatic medullary thyroid cancer and refractory renal cell carcinoma.
Liver safety of Cabozantinib
Cabozantinib is associated with a low rate of serum enzyme elevations during treatment and has been implicated with rare instances of clinically apparent, acute liver injury, some of which have been severe.
Mechanism of action of Cabozantinib
Cabozantinib (ka" boe zan' ti nib) is an orally available, small molecule, multi-kinase inhibitor with activity against hepatocyte growth factor receptor (MET), vascular endothelial growth factor receptor 2 (VEGFR-2), and rearranged during transfection (RET), cell surface tyrosine kinase receptors which are overexpressed in several forms of cancer. Cabozantinib has been evaluated as therapy of several forms of advanced and metastatic carcinomas and has shown efficacy in medullary thyroid and renal cell carcinoma.
FDA approval information for Cabozantinib
Cabozantinib received accelerated approval for use in the United States in 2012 for therapy of medullary thyroid cancer after failure of other therapies.
Clinical use of Cabozantinib
Indications were expanded in 2016 to include advanced renal cell carcinoma in addition to medullary thyroid cancer.
Dosage and administration for Cabozantinib
For therapy of medullary thyroid cancer, cabozantinib is available as capsules of 20 and 80 mg under the brand name Cometriq, and the recommended dose is 140 mg orally once daily. For treatment of advanced renal cell carcinoma, cabozantinib is available as tablets of 20, 40 and 60 mg under the brand name Cabometyx, and the recommended dose is 60 mg orally once daily.
Side effects of Cabozantinib
Common side effects include diarrhea, fatigue, nausea, constipation, anorexia, weight loss, hand-foot syndrome, stomatitis, hypertension, change in hair color, thrombocytopenia, neutropenia, anemia, rash and fever. Other uncommon, but potentially severe side effects include thrombotic events including myocardial infarction, stroke and arterial thromboses, osteonecrosis of the jaw, posterior leukoencephalopathy and fetal toxicity.
The article on Cabozantinib is a stub. YOU can help Wikimd by expanding it!
Medication resources
Learn more
About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.
Our mission: Provide up to date physician reviewed health, nutrition and wellness information.
Join us: Do not trust amateurs with your life! Join us in this effort!
 Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |
Quick links: Medicine Portal | Encyclopedia | Gray's Anatomy | Topics | Diseases | Drugs | Wellness | Obesity | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Cabozantinib">Cabozantinib</a>
- Individual results may vary for weight loss from our sponsors.