Capravirine
Capravirine
Capravirine (pronounced as kap-rah-vi-reen) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that was under development for the treatment of HIV and AIDS.
Etymology
The term "Capravirine" is derived from the Latin word 'capra' meaning goat and 'virine' from the English word 'virion', a term used to refer to a single viral particle. The name signifies the drug's ability to target and inhibit the replication of viral particles, much like a goat targets and consumes vegetation.
Usage
Capravirine was designed to be used in combination with other antiretroviral agents for the treatment of HIV-1 infection in patients with viral resistance to currently available NNRTIs and protease inhibitors. However, its development was discontinued in the phase II trials due to insufficient efficacy.
Mechanism of Action
As an NNRTI, Capravirine binds to reverse transcriptase, a key enzyme in the life cycle of HIV, and prevents it from converting the viral RNA into DNA, a process called reverse transcription. By inhibiting this process, Capravirine prevents the virus from multiplying and can reduce the amount of virus in the body.
Related Terms
- Non-nucleoside reverse transcriptase inhibitors (NNRTIs): A class of antiretroviral drugs that inhibit the reverse transcriptase enzyme.
- Reverse transcriptase: An enzyme that converts RNA into DNA, allowing the virus to integrate into the host cell and replicate.
- HIV: Human Immunodeficiency Virus, the virus that causes AIDS.
- AIDS: Acquired Immunodeficiency Syndrome, a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV).
External links
- Medical encyclopedia article on Capravirine
- Wikipedia's article - Capravirine
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