Carmofur

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Carmofur

Carmofur (pronounced: /ˈkɑːrmoʊfɜːr/) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, a type of chemotherapy drug.

Etymology

The term "Carmofur" is derived from the chemical name N-carbamoyl-5-fluorouracil. The "-fur" suffix is common in many fluoropyrimidine drugs.

Usage

Carmofur is used in the treatment of various types of cancer, including breast cancer, colorectal cancer, and gastric cancer. It works by inhibiting the enzyme thymidylate synthase, which is necessary for DNA replication and repair. This inhibition leads to DNA damage and cell death in rapidly dividing cancer cells.

Side Effects

Like many chemotherapy drugs, Carmofur can have several side effects. These may include nausea, vomiting, diarrhea, and neutropenia. It can also cause hand-foot syndrome, a condition characterized by redness, swelling, and pain in the hands and feet.

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