Wikimd logo

W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,590 pages, 4,139,107 edits & 37,811,477 views.

Free unbiased diet, health and wellness info!


From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search
Ceritinib structure.svg

Information about Ceritinib

Ceritinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC). 

Use in Cancer

Ceritinib is approved to treat:

  • Non-small cell lung cancer that is ALK positive and has metastasized (spread to other parts of the body). It is used in adults.

Ceritinib is also being studied in the treatment of other types of cancer.

Liver safety

Ceritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury

Mechanism of action of Ceritinib

Ceritinib (se ri' ti nib) is a small molecule tyrosine kinase receptor inhibitor with potent activity against anaplastic lymphoma kinase (ALK) that is rearranged and mutated in selected cancers including approximately 5% of non-small cell lung cancer (NSCLC).  The mutated, rearranged ALK promotes unregulated cell growth and proliferation and is overexpressed in some cancer cells.  Ceritinib has been found to inhibit mutated ALK in cell culture and in several clinical trials was found to induce objective responses in a proportion of patients with advanced ALK-positive NSCLC. 

FDA approval information for Ceritinib

Ceritinib received accelerated approval for use crizotinib-refractory, ALK-positive NSCLC in the United States in 2014.  Ceritinib is available in capsules of 150 mg under the brand name Zykadia. 

Dosage and administration for Ceritinib

The recommended initial dose is 750 mg (5 capsules) once daily, continued until progressive disease or intolerable toxicity occurs. 

Side effects of Ceritinib

Side effects are common and include diarrhea, nausea and vomiting, abdominal pain, fatigue, anorexia and constipation.  Uncommon, but potentially severe side effects include severe diarrhea leading to dehydration and renal failure, interstitial lung disease, prolongation of the QTc interval, bradycardia, hyperglycemia, and embryo-fetal toxicity.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ


Cost and Coupons - Ceritinib

Reviews for Ceritinib

Learn more about Ceritinib

Latest research - Ceritinib

Clinical trials

External links

Medicine icon
Medicine icon

This WikiMD article Ceritinib is a stub. If you are familiar with the topic Ceritinib, you can help us. Paid editors welcome!


Ceritinib is part of WikiMD's free ^articles!

^Ceritinib (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available