Information about Chlordiazepoxide
Liver safety of Chlordiazepoxide
As with other benzodiazepines, chlordiazepoxide therapy is not associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from chlordiazepoxide has been reported, but is very rare.
Mechanism of action of Chlordiazepoxide
Chlordiazepoxide (klor" dye az" e pox' ide) is the prototype of benzodiazepines used in the therapy of anxiety and acute alcohol withdrawal. The antianxiety (anxiolytic) activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor.
FDA approval information for Chlordiazepoxide
Chlordiazepoxide was approved in the United States in 1960 and for many years was one of the most prescribed medications. Currently, it is not commonly used, having been replaced by benzodiazepines with more favorable pharmacokinetics, half-life and tolerance.
Clinical use of Chlordiazepoxide
Dosage and administration for Chlordiazepoxide
Chlordiazepoxide is available in multiple generic forms and under the brand name of Librium in capsules of 5, 10 and 25 mg. The recommended initial dose for adults is 5 to 10 mg three to four times per day, but higher doses are used for severe anxiety disorders. Chlordiazepoxide is also available for parenteral administration (100 mg/ampule) for use in acute anxiety, preoperative sedation and acute alcohol withdrawal syndromes. In addition, combinations of chlordiazepoxide with clidinium bromide or amitriptyline have been marketed under generic as well as brand names (Librax and Limbitrol).
Side effects of Chlordiazepoxide
The most common side effects of chlordiazepoxide are dose related and include drowsiness, lethargy, ataxia, dysarthria and dizziness. Tolerance develops to these side effects, but tolerance may also develop to the anxiolytic effects.
- Diazepam (Oral)
Drug class for Chlordiazepoxide