Chlordiazepoxide

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Information about Chlordiazepoxide

Chlordiazepoxide is an orally available benzodiazepine used for therapy of anxiety and alcohol withdrawal syndromes. 

Liver safety of Chlordiazepoxide

As with other benzodiazepines, chlordiazepoxide therapy is not associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from chlordiazepoxide has been reported, but is very rare.

Mechanism of action of Chlordiazepoxide

Chlordiazepoxide (klor" dye az" e pox' ide) is the prototype of benzodiazepines used in the therapy of anxiety and acute alcohol withdrawal.  The antianxiety (anxiolytic) activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor. 

FDA approval information for Chlordiazepoxide

Chlordiazepoxide was approved in the United States in 1960 and for many years was one of the most prescribed medications.  Currently, it is not commonly used, having been replaced by benzodiazepines with more favorable pharmacokinetics, half-life and tolerance. 

Clinical use of Chlordiazepoxide

Indications include anxiety disorders and alcohol withdrawal syndrome. 

Dosage and administration for Chlordiazepoxide

Chlordiazepoxide is available in multiple generic forms and under the brand name of Librium in capsules of 5, 10 and 25 mg.  The recommended initial dose for adults is 5 to 10 mg three to four times per day, but higher doses are used for severe anxiety disorders.  Chlordiazepoxide is also available for parenteral administration (100 mg/ampule) for use in acute anxiety, preoperative sedation and acute alcohol withdrawal syndromes.  In addition, combinations of chlordiazepoxide with clidinium bromide or amitriptyline have been marketed under generic as well as brand names (Librax and Limbitrol). 

Side effects of Chlordiazepoxide

The most common side effects of chlordiazepoxide are dose related and include drowsiness, lethargy, ataxia, dysarthria and dizziness.  Tolerance develops to these side effects, but tolerance may also develop to the anxiolytic effects.

Benzodiazipines

Anticonvulsants Drugs

Drug class for Chlordiazepoxide

Anticonvulsants, and Benzodiazepines]
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