Cilostazol
Cilostazol
Cilostazol (pronounced: si-los-ta-zol) is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease. It is manufactured and sold under the brand name Pletal by Otsuka Pharmaceutical Co.
Etymology
The term "Cilostazol" is derived from the systematic IUPAC name 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone. The name is a combination of parts of the chemical structure of the drug.
Usage
Cilostazol is a phosphodiesterase 3 inhibitor that works by inhibiting platelet aggregation and dilating arteries, which increases blood flow to limbs and helps alleviate symptoms of intermittent claudication.
Related Terms
- Peripheral vascular disease: A circulatory condition in which narrowed blood vessels reduce blood flow to the limbs.
- Intermittent claudication: A condition that causes pain in the legs due to inadequate blood flow to the muscles.
- Phosphodiesterase inhibitor: A drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype.
Side Effects
Common side effects of Cilostazol include headache, diarrhea, abnormal stools, increased heart rate, and palpitations. Serious side effects may include a decrease in white blood cells, heart failure, and allergic reactions.
See Also
External links
- Medical encyclopedia article on Cilostazol
- Wikipedia's article - Cilostazol
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