Cinobufagin
Cinobufagin (pronounced: sin-o-buff-a-gin) is a bioactive compound derived from the skin and parotid venom glands of the Asiatic toad (Bufo gargarizans). It is a member of the bufadienolide family of compounds, which are known for their cardiotonic, anticancer, and antimicrobial properties.
Etymology
The term "Cinobufagin" is derived from the Latin Cinobufa, referring to the Asiatic toad, and -gin, a common suffix for compounds isolated from natural sources.
Pharmacology
Cinobufagin has been studied for its potential therapeutic applications, particularly in the field of oncology. It has been found to induce apoptosis in various cancer cell lines, including lung, liver, and breast cancer cells. This is believed to be due to its ability to inhibit the Na+/K+-ATPase pump, leading to an increase in intracellular calcium levels and subsequent activation of the apoptotic pathway.
Related Compounds
Cinobufagin is structurally related to other bufadienolides such as bufalin, resibufogenin, and arenobufagin. These compounds share a similar steroid-like structure and exhibit similar biological activities.
Therapeutic Use
While cinobufagin is not currently approved for use in humans, preclinical studies suggest it may have potential as a novel anticancer agent. Further research is needed to fully understand its mechanism of action and to assess its safety and efficacy in clinical trials.
See Also
External links
- Medical encyclopedia article on Cinobufagin
- Wikipedia's article - Cinobufagin
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