W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
29,022 pages, 4,107,471 edits & 35,725,970 views.

Free unbiased diet, health and wellness info!

Cis-urocanic acid

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

A derivative of the amino acid histidine, formed in the mammalian skin from trans-urocanic acid upon ultraviolet radiation, and protodynamic agent, with potential anti-inflammatory and antiproliferative activity. Upon intravesical instillation of cis-urocanic acid (cis-UCA), this agent is protonated at the imidazolyl moiety in the mildly acidic extracellular tumor environment and penetrates into the cancer cell. Once inside the cell and due to the slightly alkaline pH inside the tumor cell, cis-UCA is deprotonated, i.e. the imidazolyl proton is released into the cytosol which eventually raises the intracellular acidity. This acidification impairs many cellular processes, such as metabolic activity, and may lead to cell cycle arrest, an induction of cellular apoptosis and necrotic cell death. In addition, cis-UCA enhances ERK and JNK signaling pathways by inhibiting the activity of serine/threonine and tyrosine phosphatases.

Learn more about Cis-urocanic acid

Latest research (Pubmed)


External links


WikiMD needs you!

This WikiMD article Cis-urocanic acid is a stub.
If you are a healthcare professional familiar with the topic Cis-urocanic acid, or
A subject matter expert or authority on Cis-urocanic acid, you can help us.
About | Mission | Paid editors welcome!

Cis-urocanic acid is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.