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Cis 2 (p (1,2 diphenyl 1 butenyl)phenoxy) n methylethylamine

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Cis 2 (p (1,2 diphenyl 1 butenyl)phenoxy) n methylethylamine - a main metabolite of the selective estrogen receptor modulator tamoxifen with anti estrogen activity. N desmethyltamoxifen blocks estrogen from binding to the estrogen receptor. This may inhibit estrogen associated signaling and tumor growth in estrogen positive tumor cells. Conversion of n desmethyltamoxifen from tamoxifen is catalyzed by cytochrome p 450 enzymes 3a4 and 3a5. N desmethyltamoxifen is further hydroxylated, mainly by cyp2d6, to endoxifen, the major clinically active metabolite of tamoxifen.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Cis 2 (p (1,2 diphenyl 1 butenyl)phenoxy) n methylethylamine for any updates.

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