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Cis 3 (8 amino 1 (2 phenylquinolin 7 yl)imidazo(1,5 a)pyrazin 3 yl) 1 methylcyclobutanol

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Cis 3 (8 amino 1 (2 phenylquinolin 7 yl)imidazo(1,5 a)pyrazin 3 yl) 1 methylcyclobutanol - an orally bioavailable small molecule inhibitor of the insulin like growth factor 1 receptor (igf 1r) with potential antineoplastic activity. Linsitinib selectively inhibits igf 1r, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, igf 1r stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

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