Classic hodgkin lymphoma
a monoclonal b-cell lymphoproliferation in the vast majority of cases. It is characterized by a bimodal age distribution (15-30 years of life and late life). Epstein-barr virus has been postulated to play a role in the pathogenesis of classic hodgkin lymphoma. Morphologically, it is characterized by the presence of reed-sternberg cells and mononuclear hodgkin cells. The reed-sternberg and mononuclear hodgkin cells are cd30 positive in nearly all cases and cd15 positive in the majority of cases. Four histologic subtypes have been distinguished: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte-depleted classic hodgkin lymphoma.