Claudin18.2-redirected autologous cells
Claudin18.2-redirected autologous cells - a preparation of autologous t-lymphocytes ex vivo transduced with a lentiviral vector encoding for a chimeric antigen receptor (car) specific for the tumor-associated antigen (taa) claudin18.2 (cldn18.2; a2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-cldn18.2car-transduced t lymphocytes specifically recognize and induce selective toxicity in cldn18.2-expressing tumor cells. Cldn18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.
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