Clear cell sarcoma
Clear Cell Sarcoma
Clear cell sarcoma (pronounced: kleer sel sahr-KOH-muh), also known as malignant melanoma of soft parts, is a rare form of cancer that primarily affects young adults.
Etymology
The term "clear cell" refers to the appearance of the cancer cells under a microscope, which often appear clear or pale. "Sarcoma" is derived from the Greek word 'sarx' meaning flesh and 'oma' meaning tumor, indicating a cancer that originates in the connective or supportive tissues of the body.
Definition
Clear cell sarcoma is a type of tumor that usually begins in the tendons or soft tissues of the body. It is characterized by its unique genetic features, specifically the presence of a specific chromosomal translocation, t(12;22)(q13;q12), which results in the fusion of the EWSR1 and ATF1 genes.
Symptoms
Symptoms of clear cell sarcoma may include a lump or swelling in the affected area, pain, and limited range of motion. However, symptoms can vary greatly depending on the location and size of the tumor.
Diagnosis
Diagnosis of clear cell sarcoma typically involves a combination of imaging tests, such as MRI or CT scan, and a biopsy to examine the cells under a microscope. Genetic testing may also be performed to identify the characteristic chromosomal translocation.
Treatment
Treatment for clear cell sarcoma often involves surgery to remove the tumor, followed by radiation therapy or chemotherapy to kill any remaining cancer cells. In some cases, targeted therapy or immunotherapy may be used.
Prognosis
The prognosis for clear cell sarcoma varies depending on a number of factors, including the size and location of the tumor, the patient's overall health, and the extent to which the cancer has spread at the time of diagnosis.
Related Terms
External links
- Medical encyclopedia article on Clear cell sarcoma
- Wikipedia's article - Clear cell sarcoma
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