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Clearance (in physiology and toxicology)

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Clearance (in physiology and toxicology): Volume of blood or plasma or mass of an organ effectively cleared of a substance by elimination (metabolism and excretion) divided by time of elimination. Note : Total clearance is the sum of the clearances of each eliminating organ or tissue for that component (in pulmonary toxicology) Volume or mass of lung cleared divided by time of elimination; used qualitatively to describe removal of any inhaled substance which deposits on the lining surface of the lung. (in renal toxicology) Quantification of the removal of a substance by the kidneys by the processes of filtration and secretion; clearance is calculated by relating the rate of renal excretion to the plasma concentration.


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