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Information about Dipyridamole

Dipyridamole is a vasodilator and inhibitor of platelet aggregation that is used to decrease the risk of thromboembolic complications and recurrence of stroke in patients known to have atherosclerotic cerebrovascular disease. 


Liver safety of Dipyridamole

Dipyridamole is associated with a low rate of serum enzyme elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Dipyridamole

Dipyridamole (dye' pir id' a mole) is a pyrimidine analogue that is used as an antiplatelet agent to decrease the risk of thromboembolic complications in patients at high risk, such as with a prosthetic heart value, with hypercoagulable states and with a history of arterial thromboses (heart attack, stroke).  Dipyridamole is usually given in combination with other Anticoagulants or antiplatelet agents such as warfarin or aspirin. 

FDA approval information for Dipyridamole

Dipyridamole was approved for use in the United States in 1961 as an adjunct to coumarin Anticoagulants in prevention of thromboembolic complications of cardiac valve replacements. 

Dosage and administration for Dipyridamole

Dipyridamole is available in tablets of 25, 50 and 75 mg in generic forms and under the trade name Persantine.  It is also available in fixed combinations with aspirin under the name Aggrenox as prophylaxis to reduce the risk of stroke in patients with previous history of ischemic stroke or transient ischemic attacks.  The typical recommended dose varies by indication, but for adults is generally 150 to 400 mg daily in divided doses.  Dipyridamole is also available as a solution for injection for use as an alternative to exercise in thallium myocardial perfusion imaging (“dipyridamole stress test”). 

Dosage and administration for Dipyridamole

Dipyridamole is generally well tolerated, but side effects can include headache, dizziness, flushing, chest pain, gastrointestinal upset, nausea, diarrhea, rash and pruritus.

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