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Clinical specificity

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The proportion of individuals who do not have a specified clinical disorderand whose test results indicate that the disorder is not present.

The following hypothetical example illustrates clinical sensitivity and specificity: Aclinician determines that 100 patients have recessively inherited disease C, based onsymptoms, family history, and ethnicity. Upon genetic testing, 60 of the patients are shownto have 2 mutations in gene D. Thus, the clinical sensitivity is 60%. The remaining 40patients may have only one or no mutations in D. The same clinician sees 100 patients who do not have disease C. When tested, 5 of the individuals are shown to have 2 mutations in D.

Thus, the clinical specificity is 95%.


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