Clomipramine

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Information about Clomipramine

Clomipramine is a tricyclic antidepressant used in the therapy of obsessive-compulsive disorder. Clomipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute liver injury.

Mechanism of action of Clomipramine

Clomipramine (kloe mip' ra meen) is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin reuptake within synaptic clefts in the central nervous system, thus increasing brain serotonin levels. Clomipramine also has some blocking activity at postsynaptic dopamine receptors.

FDA approval information for Clomipramine

Clomipramine is used in the therapy of obsessive-compulsive disorder and was approved for this indication in the United States in 1989.

Dosage and administration for Clomipramine

Clomipramine is available in generic forms and under the brand names of Anafranil in capsules of 25, 50 and 75 mg. The typical recommended dose for obsessive compulsive disorder is 25 mg daily, increasing to at least 100 mg daily with a maximum dose of 250 mg daily.

Side effects of Clomipramine

Common side effects include dizziness, headache, insomnia, somnolence, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention. Rare, but potentially severe adverse events include suicidal ideation and behavior, worsening of depresssion or mania, glaucoma, serotonin syndrome, hypersensitivity reactions and seizures.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


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