Clonidine lauriad - an extended release, proprietary mucoadhesive buccal tablet formulation containing the hydrochloride salt form of clonidine, the imidazoline derivative and adrenergic alpha 2 receptor agonist, with anti inflammatory activity. Upon contact of the tablet with the buccal mucosa, clonidine binds to the adrenergic receptors on macrophages and lymphocytes and may reduce the release of pro inflammatory mediators such as tumor necrosis factor alpha (tnfalpha). As a result, this agent may prevent chemoradiation therapy induced mucositis.
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