WikiMD is the world's largest medical encyclopedia with
28,738 pages, 4,106,629 edits & 35,539,243 views.
Chlordiazepoxide
Information about Chlordiazepoxide
Chlordiazepoxide is an orally available benzodiazepine used for therapy of anxiety and alcohol withdrawal syndromes.
Liver safety of Chlordiazepoxide
As with other benzodiazepines, chlordiazepoxide therapy is not associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from chlordiazepoxide has been reported, but is very rare.
Mechanism of action of Chlordiazepoxide
Chlordiazepoxide (klor" dye az" e pox' ide) is the prototype of benzodiazepines used in the therapy of anxiety and acute alcohol withdrawal. The antianxiety (anxiolytic) activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor.
FDA approval information for Chlordiazepoxide
Chlordiazepoxide was approved in the United States in 1960 and for many years was one of the most prescribed medications. Currently, it is not commonly used, having been replaced by benzodiazepines with more favorable pharmacokinetics, half-life and tolerance.
Clinical use of Chlordiazepoxide
Indications include anxiety disorders and alcohol withdrawal syndrome.
Dosage and administration for Chlordiazepoxide
Chlordiazepoxide is available in multiple generic forms and under the brand name of Librium in capsules of 5, 10 and 25 mg. The recommended initial dose for adults is 5 to 10 mg three to four times per day, but higher doses are used for severe anxiety disorders. Chlordiazepoxide is also available for parenteral administration (100 mg/ampule) for use in acute anxiety, preoperative sedation and acute alcohol withdrawal syndromes. In addition, combinations of chlordiazepoxide with clidinium bromide or amitriptyline have been marketed under generic as well as brand names (Librax and Limbitrol).
Side effects of Chlordiazepoxide
The most common side effects of chlordiazepoxide are dose related and include drowsiness, lethargy, ataxia, dysarthria and dizziness. Tolerance develops to these side effects, but tolerance may also develop to the anxiolytic effects.
Benzodiazipines
- Alprazolam
- Chlordiazepoxide
- Diazepam (Oral)
- Estazolam
- Flurazepam
- Lorazepam
- Midazolam
- Oxazepam
- Quazepam
- Temazepam
- Triazolam
Anticonvulsants Drugs
Drug class for Chlordiazepoxide
Anticonvulsants, and Benzodiazepines]
Cost and Coupons - Chlordiazepoxide
- GoodRx compare cost & coupons for Chlordiazepoxide
- Find the lowest cost of Chlordiazepoxide
- Search for Coupons for Chlordiazepoxide
Reviews for Chlordiazepoxide
Learn more about Chlordiazepoxide
- Dailymed label info
- Scientific articles
- Drug portal Chlordiazepoxide
- toxicity info on Chlordiazepoxide
- FDA Chlordiazepoxide
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Chlordiazepoxide is a stub.
If you are a healthcare professional familiar with the topic Chlordiazepoxide, or
A subject matter expert or authority on Chlordiazepoxide, you can help us.
About | Mission | Paid editors welcome!
| Chlordiazepoxide is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
|---|
| Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP* |
