WikiMD is the world's largest medical encyclopedia with
28,728 pages, 4,106,589 edits & 35,539,243 views.
Clobazam
Information about Clobazam
Clobazam is a benzodiazepine that is used as an anticonvulsant in the therapy of severe childhood epilepsy.
Liver safety of Clobazam
Therapy with clobazam has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from clobazam has yet to be reported and must be rare, if it occurs at all.
Mechanism of action of Clobazam
Clobazam (kloe' ba zam) is a unique 1,5 benzodiazepine which is used in the United States as an anticonvulsant, but is available in other countries for therapy of anxiety as well as epilepsy. The anticonvulsant activity of clobazam appears to be mediated by its ability to enhance gamma-aminobutyric acid (GABA) medicated inhibition of synaptic transmission via binding to the GABA-A receptor.
FDA approval information for Clobazam
Clobazam was approved for use in the United States in 2011 as an anticonvulsant to be used either alone or in combination with other agents as therapy of the severe form of childhood epilepsy known as Lennox-Gastaut syndrome.
Dosage and administration for Clobazam
Clobazam is available in tablets of 5, 10 and 20 mg under the brand name Onfi in the United States and Frisium and Urbanol elsewhere. The recommended initial dose is 5 mg once or twice daily, with subsequent increases to a usual maintenance dose of 20 mg twice daily. The dose should be increased and tapered gradually.
Side effects of Clobazam
The most common side effects are dose related and include dizziness, somnolence, impaired concentration, nervousness, aggression, antegrade amnesia, headache, fatigue, nausea and weakness. Clobazam can also lead to physical dependence and sudden discontinuation can cause withdrawal symptoms and rebound seizure activity.
Cost and Coupons - Clobazam
- GoodRx compare cost & coupons for Clobazam
- Find the lowest cost of Clobazam
- Search for Coupons for Clobazam
Reviews for Clobazam
Learn more about Clobazam
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Clobazam is a stub.
If you are a healthcare professional familiar with the topic Clobazam, or
A subject matter expert or authority on Clobazam, you can help us.
About | Mission | Paid editors welcome!
| Clobazam is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
|---|
| Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP* |
