Cmet car-mrna-electroporated autologous t lymphocytes
Cmet car-mrna-electroporated autologous t lymphocytes - a preparation of autologous, genetically-engineered t-lymphocytes that have been electroporated with an mrna encoding a chimeric antigen receptor (car) consisting of an anti-human hepatocyte growth factor receptor (hgfr or cmet) single chain variable fragment (scfv), with potential antineoplastic activities. Upon administration, autologous mrna-modified anti-cmet car-t cells direct t-cells to cmet-expressing tumor cells, which induces selective toxicity against cmet-expressing tumor cells and causes tumor cell lysis. Cmet, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.
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